Computational Pathology Group

The Computational Pathology Group develops, validates and deploys novel medical image analysis methods based on deep learning technology.

Automated tumor detection
Automated tumor detection

Highlights

Keynote at the European Congress of Pathology 2019

Keynote at the European Congress of Pathology 2019

Jeroen van der Laak presented his keynote lecture entitled 'The rise of Artificial Intelligence and its impact on histopathology' at the 31rst European Computational Pathology Congress in the Acropolis Convention Centre in Nice, France. Read more →

All highlights

Vacancies & Student projects

Student project

Deep Learning to predict recurrence in triple negative breast cancer (TNBC)

Aim of the presently proposed ‘proof of concept‘ study is to develop digital pattern recognition algorithms (more specifically: deep neural networks) for the extraction of morphological features from scanned H&E stained tissue sections from TNBC which are indicative for the risk of recurrence.

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Student project

Deep Learning to detect artifacts in whole slide images

The goal of this project is to develop a deep learning model that can detect and classify the different types of artifacts observed in whole slide images.

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Student project

Deep Learning for the differentiation of STIC lesions

The goal is to develop a deep learning algorithm for the differentiation of STIC lesions from normal fallopian tube epithelium. The digital pathology images of a cohort of both STIC lesions and normal tubal epithelium from BRCA1/2 carries will be available. The output will be an algorithm that can identify aberrant tubal epithelium with a high sensitivity.

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Projects

AQUILA

The goal of AQUILA is to investigate the prognostic value of Tumor Infiltrating Lymphocytes (TILs) in breast and colon cancer.

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CAMELYON17

ISBI 2017 challenge to evaluate algorithms for automated detection and classification of breast cancer metastases in whole-slide images of histological lymph node sections.

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DCIS

The aim of this project is to use deep learning for histological assessment of the stroma for improved risk stratification of ductal carcinoma in situ (DCIS) patients.

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Deep PCA

In this project, we will combine deep learning and digitized whole-slide imaging of prostate cancer for reproducible extraction of quantitative biomarkers.

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ExaMode

The aim of ExaMode is to collect training data with limited human interaction for the processing of exascale volumes of healthcare data.

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Multimot

MULTIMOT aims to build an open data ecosystem for cell migration research, through standardization, dissemination and meta-analysis efforts.

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AI to predict lung cancer immunotherapy response

In this project we develop deep learning algorithms for the extraction of features from scanned H&E and immunohistochemically stained tissue sections from lung cancer that carry predictive value in the context of immunotherapy treatment response.

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PRIM4BC

Detecting biomarkers for improved prognosis for triple negative breast cancer by combining histopathology, multiplex immunohistochemistry and Deep Learning.

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STITPRO II

Project with focus on the extension of open-source software ASAP that includes functionality for study and case management.

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SysMIFTA

The investigation of the role of immune cell subsets in interstitial fibrosis and tubular atrophy in renal allografts, using multiplex immunohistochemistry and Deep Learning.

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Tumor-Stroma Ratio

We aim at developing automatic and reproducible quantification of Tumor-Stroma Ratio in Whole-Slide Images using Deep Learning.

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Tumor budding

In this project, we will develop and validate digital image analysis algorithms for quantification of tumor budding from scanned whole slide images.

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Members

Caner Mercan

Caner Mercan

Postdoctoral researcher

David Tellez

David Tellez

PhD student

Emiel Stoelinga

Emiel Stoelinga

Master student

Francesco Ciompi

Francesco Ciompi

Assistant Professor

Geert Litjens

Geert Litjens

Assistant professor

Hans Pinckaers

Hans Pinckaers

PhD student

Jasper Linmans

Jasper Linmans

PhD student

Jeroen van der Laak

Jeroen van der Laak

Associate professor/Group leader

Koen Dercksen

Koen Dercksen

Master student

Leander van Eekelen

Leander van Eekelen

Master student

Maschenka Balkenhol

Maschenka Balkenhol

Pathology resident and PhD student

Maud Wekking

Maud Wekking

Research technician

Merijn van Erp

Merijn van Erp

Scientific programmer

Meyke Hermsen

Meyke Hermsen

PhD student

Michel Kok

Michel Kok

Master student

Miriam Groeneveld

Miriam Groeneveld

Research Software Engineer

Oscar Geessink

Oscar Geessink

PhD student

Patrick Sonsma

Patrick Sonsma

Master student

Péter Bándi

Péter Bándi

PhD student

Thomas de Bel

Thomas de Bel

PhD student

Witali Aswolinskiy

Witali Aswolinskiy

Postdoctoral researcher

Wouter Bulten

Wouter Bulten

PhD student

Yiping Jiao

Yiping Jiao

PhD student

Zaneta Swiderska-Chadaj

Zaneta Swiderska-Chadaj

Postdoctoral researcher