PANDA Challenge

PANDA Challenge logo

With 1.1 million new diagnoses every year, prostate cancer (PCa) is the most common cancer in men in developed countries. The biopsy Gleason grading system is the most important prognostic marker for prostate cancer but suffers from significant inter-observer variability, limiting its usefulness for individual patients. The Gleason grade is determined by pathologists on hematoxylin and eosin (H&E) stained tissue specimens based on the architectural growth patterns of the tumor.

Automated deep learning systems have shown promise in accurately grading prostate cancer. Several studies have shown that these systems can achieve pathologist-level performance. A large multi-center evaluation on diagnostic data is still missing. In this challenge, we strive to improve on these works by publishing the most extensive multi-center dataset on Gleason grading as of yet. The training set consists of up to 11.000 whole-slide images of digitized H&E-stained biopsies originating from two centers. This is the largest public whole-slide image dataset available, roughly eight times the size of the CAMELYON17 challenge. Furthermore, in contrast to previous challenges, we do not use small tissue micro-arrays, but full diagnostic biopsy images. Using a sizeable multicenter test set, graded by expert uropathologists, we will evaluate challenge submissions on their applicability to a clinically relevant task.

Task

The task of the challenge is to design a system that can automatically detect prostate cancer, and if there is cancer present, assign a grade group. The biopsy-level grade should follow the ISUP grade group system.

Participate in the challenge

The challenge is hosted on Kaggle. Please signup at the Kaggle webite.

Organizers

The PANDA challenge is organized in collaboration with researchers from the Karolinska Institute (Sweden).

People

Wouter Bulten

Wouter Bulten

PhD Candidate

 Peter Ström

Peter Ström

 Kimmo Kartasalo

Kimmo Kartasalo

Hans Pinckaers

Hans Pinckaers

PhD Candidate

 Martin Eklund

Martin Eklund

Geert Litjens

Geert Litjens

Assistant Professor

Publications

  • W. Bulten, H. Pinckaers, H. van Boven, R. Vink, T. de Bel, B. van Ginneken, J. van der Laak, C. de Hulsbergen-van Kaa and G. Litjens, "Automated deep-learning system for Gleason grading of prostate cancer using biopsies: a diagnostic study", Lancet Oncology, 2020;21(2):233-241. Abstract/PDF DOI PMID Cited by ~29